The indoor simulation is adopted instead of field experiment to minimize the experimental frequency of the millimeter wave passive detector in field. In view of the process of millimeter wave radiometer in terminal-sensitive projectile detecting armor target, a mathematical model of indoor hardware-in-the-loop simulation system is established, an equivalent mathematic model of indoor simulation system and field detection is built, and a millimeter wave radiometer hardware-in-the-loop simulation system is designed. Finally, the hardware-in-the-loop simulation results are compared with the measured results on the tower. The results show the correctness of the millimeter wave radiometer hardware-in-the-loop simulation system and the equivalent relationship of the proposed model. It can be used for the hardware-in-the-loop simulation test for the development and production test of terminal sensitive projectiles.