In order to solve the problem of that magnetic resonant coupling setting system can not work effectively in complex ferromagnetic environment, an analytical expression of eddy current losses of magnetic resonant coupling setting system is derived based on the basic theory of the electromagnetic quasi-static field, and the influence factors of the energy transmission system are analyzed. Numerical simulation and experiment study are conducted on the fuze setting system in different environments. The results show that theoretical analysis results are consistent with the numerical calculation and experimental results. The system is not working properly mainly due to eddy current loss, which is related to the resonant frequency of the system, and the permeability and conductivity of dielectric material. When ferrite bead is added in slot gap of steel media, the fuze setting system can work effectively after 20 ms, and can meet the requirement. The conclusion on magnetic resonant coupling setting system is helpful to engineering design in complex environment.