Abstract: Inspired by the immune mechanism of organisms immune system，the local optimize performance of gravitational search algorithm (GSA) was improved by the immune information processing mechanism，and the GSA with immunity was proposed. The proposed algorithms have both the advantages of the original GSA and the immune information processing mechanism of immune system，which can improve the abilities of seeking the global excellent result and evolution speed. The computer simulation result in examples demonstrates that the proposed algorithms are superior to the original GSA.