Synthesis of 2-methoxy-35-dinitryl-6-azidepyrazine

Abstract

Abstract: MDNAP is a precursor for novel energetic compounds. 2-methoxy-6-chlorin pyrazine (MCP) was first synthesized from raw material 2,6-dichlorin pyrazine by substituting chlorine with methoxyl with a yield of 81%. 2-methoxy-3,5-dinitryl-6-chlorin pyrazine (MDNCP) was obtained by the nitration of MCP with mixed nitric and sulfuric acids under facile conditions with a yield of 75%. 2-methoxy -3,5-dinitryl-6-azide pyrazine (MDNAP) was synthesized from MDNCP by the zaide substitution of MDNCP with a yield of 60%. Therein, all the intermediates were characterized by IR, H₁ NMR, ESI-MS and EI-MS.

Key words: organic chemistry, 2-methoxy-3,5-dinitryl-6-azidepyrazine, pyrazine, azide substitution, nitration

CLC Number:

TB34

LIU Yao-peng, CHEN Hua-xiong, CHEN Shu-sen, JIN Shao-hua. Synthesis of 2-methoxy-35-dinitryl-6-azidepyrazine[J]. Acta Armamentarii, 2010, 31(10): 1357-1362.

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