Abstract: Multiple missiles in the cooperative guidance may communicate via a random network in virtue of packet loss and communication delay, resulting in an unsustainable connected or even interrupted communication topology. Hence, a distributed cooperative guidance strategy is proposed. Based on sampled data, a distributed linear consensus protocol is designed, and a deviation system is constructed, which can be stabilized such that all the coordination variables of missiles asymptotically achieve a common state. Multiple missiles disconnect to the communication network and are guided to a target independently when they approach the target. Theoretical analysis reveals that the proposed consensus protocol doesn’t make any requirements on the communication topology at any time, in other words, the communication topology may be disconnected or even be interrupted. Finally, two simulation examples with regard to cooperative guidance with unsustainable connected communication topology are given. The presented guidance strategy can be used to ensure the impact times of all the missiles being the same.